Pylon PL Series | Shionogi Healthcare

Cold symptoms
come in combinations.

Cold symptoms generally come in combinations.
That’s why colds should never be taken lightly.
SHIONOGI’s cold medications, including Pylon PL Granules Pro containing the same amounts of active
ingredients as prescription-grade drugs, have been developed to tackle various combined symptoms of colds.
To relieve multiple cold symptoms, choose a cold medicine that tackles combined cold symptoms.
From SHIONOGI, in constant efforts to fight against infections

Cold symptoms noted when taking cold medicine

= Pylon PL Granules Pro purchasers (n=156)
= Pylon PL series purchasers (n=156)
= Pylon PL Granules Pro recognizers and non-purchasers (n=103)
= Pylon PL series non-recognizers (over-the-counter cold medicine users) (n=104)

* Surveyed by Shionogi Healthcare, November 2021

For relief of a combination of cold symptoms,
the series

For relief of cold symptoms, such as discomforting sore throat, fever, and a runny nose Contains the same amounts of active ingredients as prescription-grade drugs

Manufacturer’s suggested retail price
12 packs: JPY 1,680 (excluding tax)
18 packs: JPY 2,280 (excluding tax)

Contains the same amounts of active ingredients as prescription-grade drugs^*1
Taking this medication four times a day helps relieve discomforting cold symptoms.

*1 The amounts of salicylamide, acetaminophen, anhydrous caffeine, and promethazine methylenedisalicylate (in one pack)

Degree of improvement (overall evaluation) [%]

Number of cases	381 cases for which overall results have been judged for five clinical trial reports of PL Combination Granules	・These clinical trial data are for the prescription drug PL Combination Granules. When using Pylon PL Granules Pro, please follow the usage and dosage (one pack per dose, four times a day). If symptoms do not improve after taking five or six doses of this product, stop taking the product and consult a physician, pharmacist or registered distributor, bringing the package insert with you. ・Do not use Pylon PL Granules Pro for individuals under 15 years old.
Subjects	Patients with a cold
Method	All doses were administered orally at a dose of 1 g per dose, four times a day, and the overall improvement rate two days after administration was evaluated in four grades (marked improvement, moderate improvement, slight improvement, and no change).
Duration	Two days

Number of cases	381 cases for which overall results have been judged for five clinical trial reports of PL Combination Granules
Subjects	Patients with a cold
Method	All doses were administered orally at a dose of 1 g per dose, four times a day, and the overall improvement rate two days after administration was evaluated in four grades (marked improvement, moderate improvement, slight improvement, and no change).
Duration	Two days
・These clinical trial data are for the prescription drug PL Combination Granules. When using Pylon PL Granules Pro, please follow the usage and dosage (one pack per dose, four times a day). If symptoms do not improve after taking five or six doses of this product, stop taking the product and consult a physician, pharmacist or registered distributor, bringing the package insert with you. ・Do not use Pylon PL Granules Pro for individuals under 15 years old.

＜About safety＞: Of the 422 cases reported in five clinical trials, 275 cases in four reports were assessed for safety based on the type and degree of side-effect symptoms. The incidence of side effects was 7.2%, and no serious side effects were observed.

＜Effect by symptom -- improvement rate＞: The improvement rate was calculated based on the number of cases in which symptoms disappeared or were relieved two days after administration.

Pro prescription containing the maximum amount of each active ingredient^*2

Manufacturer’s suggested retail price for 24 tablets:
JPY 1,780 (excluding tax)

*2 Contains the maximum amounts of four active ingredients
as a daily dose of the cold medication Pylon PL

Pylon PL Granules Pro In an adult daily dose of four packs (1.0 g x 4)Pylon PL Tablets Pro In an adult daily dose of eight tablets

Four types of ingredients / Amount

Salicylamide (1,080 mg)
Promethazine methylenedisalicylate (54 mg)

Acetaminophen (600 mg)
Anhydrous caffeine (240 mg)

- Lactose hydrate, corn starch, sodium chloride, sucrose, and hydrous silicon dioxide are contained as additives in Pylon PL Granules Pro.
- Lactose hydrate, croscarmellose sodium, hydroxypropylcellulose, and magnesium stearate are contained as additives in Pylon PL Tablets Pro.

View details

For 11 cold symptoms,
including coughing and phlegm

Manufacturer’s suggested retail price
18 tablets: JPY 1,680 (excluding tax)
30 tablets: JPY 2,380 (excluding tax)

Six types of ingredients of Pylon PL Tablet Gold

Dextromethorphan hydrobromide hydrate
Bromhexine hydrochloride
Salicylamide
Acetaminophen
Promethazine methylenedisalicylate
Anhydrous caffeine

View details

For sore throat,
fever and a runny nose

Manufacturer’s suggested retail price
12 packs: JPY 1,250 (excluding tax)
24 packs: JPY 1,980 (excluding tax)

Manufacturer’s suggested retail price
24 tablets: JPY 1,250 (excluding tax)
48 tablets: JPY 1,980 (excluding tax)

Four types of ingredients of the Pylon PL series Pylon PL Granules/Pylon PL Tablets

Salicylamide
Acetaminophen
Promethazine methylenedisalicylate
Anhydrous caffeine

View details

Series comparison table

Ingredients and amounts (adult daily dose)		Pylon PL Granules Amount in three packs	Pylon PL Tablets Amount in six tablets	Pylon PL Granules Pro Amount in four packs	Pylon PL Tablets Pro Amount in eight tablets	Pylon PL Tablets Gold Amount in six tablets
Salicylamide	Reduces pain and fever	648mg	648mg	1,080mg	1,080mg	648mg
Acetaminophen	Reduces pain and fever	360mg	360mg	600mg	600mg	360mg
Anhydrous caffeine	Helps the function of reducing pain	144mg	144mg	240mg	240mg	144mg
Promethazine Methylenedisalicylate	Relieves a runny nose, nasal congestion and sneezing	32.4mg	32.4mg	54mg	54mg	32.4mg
Dextromethorphan hydrobromide hydrate	Relieves coughing	-	-	-	-	48mg
Bromhexine hydrochloride	Clears phlegm	-	-	-	-	12mg

Usage and dose	Adult (15 years old or over)	One pack per dose/three times daily	Two tablets per dose/three times daily	One pack per dose/four times daily	Two tablets per dose/four times daily	Two tablets per dose/three times daily
Usage and dose	Under the age of 15	Do not use this product.	Do not use this product.	Do not use this product.	Do not use this product.	Do not use this product.

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Before you catch a cold! Prepare early!

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When you catch a cold, it is important to rest well and eat well.
Utilizing cold medications is also effective when you have discomforting cold symptoms.

Before you catch a cold...

Make it a habit to wash your hands and gargle when you come home from outside.

Eighty to ninety percent of colds are caused by viruses. Washing your hands with soap and hot water and gargling with mouthwash are effective as preventive measures.

Make sure to get yourself in good physical condition in your daily life.

If your body is not in good condition, you will be more likely to be infected with a virus. Control your stress and fatigue, have a good night’s sleep, and enhance your physical strength and immunity.

Also, pay close attention to your daily meals.

Wherever possible, try to eat green and yellow vegetables and fruits, which contain a lot of vitamin C and vitamin A, which influence various immune functions.

View details of Vitamin C preparation Cinal® EX Pro

Provide a supply of fresh air into a room by ventilating it well in a timely manner.

In order to keep the air in the room clean, open the windows to let in fresh air. Since the air is dry in winter, maintain appropriate humidity with a humidifier.

If you suspect you may have a cold

The first priority is to rest.

Have a good night’s sleep in a warm room with relatively high humidity. If you sweat, wipe it off well and avoid cooling your body.

If you don’t have a fever, it is a good idea to warm yourself slowly in a bath.

The steam from the bath moisturizes the mucous membranes of your nose and throat. Take a bath with lukewarm water to avoid exhausting yourself. You should avoid staying in the bath for too long.

Try to take in sufficient nutrition even if you don’t have an appetite.